It is important to note that the comparisons performed between the Abbott and Beckman Coulter assays make no assumptions as to assay accuracy or which system is more correct/accurate. Most of the transferred reference intervals were sex-specific and were verified using healthy reference samples from the CALIPER biobank based on CLSI criteria.
Transferred reference intervals were, in general, similar to previously published CALIPER reference intervals, with some exceptions. We found a strong correlation between Abbott ARCHITECT and Beckman Coulter AU biochemical assays, allowing the transference of the vast majority (94% 30 out of 32 assays) of CALIPER reference intervals previously established using Abbott assays. The new reference intervals were directly verified using up to 100 reference samples from the healthy CALIPER cohort. Transference of CALIPER reference intervals was performed based on the CLSI guidelines C28-A3 and EP9-A2. To expand clinical application of CALIPER reference standards, the present study is aimed at transferring CALIPER reference intervals from the Abbott ARCHITECT to Beckman Coulter AU assays. The CALIPER program has established a comprehensive database of pediatric reference intervals using largely the Abbott ARCHITECT biochemical assays. CLSI-based transference of CALIPER pediatric reference intervals to Beckman Coulter AU biochemical assays.Ībou El Hassan, Mohamed Stoianov, Alexandra Araújo, Petra A T Sadeghieh, Tara Chan, Man Khun Chen, Yunqi Randell, Edward Nieuwesteeg, Michelle Adeli, Khosrow
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